Dynamic changes in the histomorphological structure of the thyroid gland of rats against the background of experimental autoimmune thyroiditis

In preclinical studies, which are conducted to study the therapeutic effectiveness and pharmacological safety of biologically active compounds for correction autoimmune thyroiditis, various experimental models this pathology used in experiment.
 work, we analyzed thyroiditis that have been past fifty years. Such an analysis made it possible choose most optimal model thyroid gland as well condition. The known search new pathogenetically justified diseases endocrine organs is a very urgent task.
 aim work was dynamics changes histomorphological structure when modeling rats using allogeneic antigen isolated from human gland.
 postoperative person antigen. Morphological were studied one, three six months after end simulation.
 It found use type immunization led parenchyma gland, characteristic thyroiditis. Already one month modeling, Gürtle cells, fibrosis, areas lymphoid infiltration registered. These pathological persisted worsened investigated easily reproduced. Pathological deepen over time comparable those occur people with Hashimoto's